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Silk-Chromophore Composite Materials for In Situ Oxygen Sensing
Silk-based Materials for Oxygen Sensing (T002586)
Background
Monitoring tissue oxygenation in vivo is critical for wound healing, organ transplants, and oncology. However, current sensors face two major hurdles:
Most sensors require secondary surgery for removal, increasing patient risk and healthcare costs.
Traditional materials can trigger...
Published: 3/13/2026
Inventor(s): David Kaplan, Thomas Falcucci, Kayla Presley, Jack Ly, Matthew Dalton, Tod Grusenmeyer
Keywords(s):
Category(s): Device, Diagnostic, Nanotechnology: sensors
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Functional Point-of-Care Dried Blood Spot Cards
SUMMARY OF PROBLEMCurrently, blood is collected and stored for further analysis on dried blood spot (DBS) cards. Uses include testing expecting mothers for fetal distress, and newborns for metabolic and congenital disorders; and is a field standard for biobanking and epidemiology.However, these cards are subject to sampling inconsistencies. Under- or...
Published: 7/7/2022
Inventor(s): Charles Mace, Jessica Brooks, Syrena Fernandes, Keith Baillargeon
Keywords(s):
Category(s): Device, Diagnostic
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Coherent Hemodynamics Spectroscopy - a non-invasive and real-time diagnostic technology to identify and monitor brain damage
SUMMARYNon-invasive and real-time optical diagnostic technology that offers new way to identify and monitor brain damage resulting from traumatic injury, stroke or vascular dementia. BACKGROUNDCerebrovascular diseases are the second leading cause of death and dementia, and the leading cause of disability worldwide. More accurate measurements of the...
Published: 3/28/2025
Inventor(s): Sergio Fantini
Keywords(s):
Category(s): Medical devices, Diagnostic
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Electronic components on paper-based substrates
Electronic components on paper-based substratesThe present disclosure relates to paper-based substrates and apparatus comprising such substrates. The apparatus may include a patterned conductive structure coupled to the paper-based substrate, wherein the patterned conductive structure responds to electromagnetic radiation. Since paper-based substrates...
Published: 1/15/2025
Inventor(s): Fiorenzo Omenetto, David Kaplan, Hu Tao
Keywords(s):
Category(s): Diagnostic
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Smart Fabrics
SUMMARYResearchers at Tufts University have developed an implantable, conductive nanothread platform capable of making enhanced measurements of multiple physiological parameters simultaneously and continuously, and reporting these measurements wirelessly. BACKGROUNDSmart devices have changed how we interact with every aspect of our lives, including...
Published: 9/30/2020
Inventor(s): Sameer Sonkusale, Rachel Owyeung
Keywords(s):
Category(s): Materials, Diagnostic
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Fluidic Devices Involving Signal Generation at Converging Fronts
DESCRIPTIONDr. Charles Mace has designed a novel multilayered paper device. First, liquid sample is transported to chambers within the device with stored reagents. Then the liquid mixtures from the chambers converge back to a reaction zone. The converging liquid fronts generate a signal that, through design and specific paper treatments, restrict signal...
Published: 9/30/2020
Inventor(s): Charles Mace, Daniel Wilson
Keywords(s):
Category(s): Device, Diagnostic
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Separation of Cells Based on Size and Affinity Using Paper Microfluidic Devices
SUMMARYTufts University investigator Charles Mace has developed a novel paper device that can be used to separate and quantify blood based on size exclusion and affinity separation. This technology is ideal for applications in personalized healthcare, point-of-care diagnostics, monitoring of livestock, and determining food or water quality.PROBLEMA...
Published: 7/7/2022
Inventor(s): Charles Mace, Syrena Fernandes, Samuel Berry
Keywords(s):
Category(s): Device, Diagnostic
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Wireless Frequency Domain Near Infrared Spectroscope for Cerebral Studies
Researchers at Tufts University have developed a miniaturized frequency domain near infrared spectroscope (mini-FD-NIRS) allowing for non-invasive measurements of absolute concentrations of oxy/deoxy-hemoglobin and other chromophores in patients and animals. Proof of concept experiments demonstrate that the measurements of chromophore concentrations...
Published: 6/5/2020
Inventor(s): Valencia Joyner Koomson, Chirag Sthalekar
Keywords(s):
Category(s): Healthcare, Imaging, Instrumentation, Diagnostic
