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SUMMARY Tufts University investigator Nikhil Nair and his team have developed a novel directed evolution workflow to rapidly engineer ammonia lyase (AL) class enzymes for large sequences that are ideal for improving kinetic properties. This technique was used to isolate previously unexplored phenylalanine ammonia lyase (PAL) enzymes with ~2.5-fold...
Published: 8/24/2023
Inventor(s): Nikhil Nair, Karishma Mohan, Vikas Trivedi, Zachary Mays, Todd Chappell
Keywords(s):
Category(s): Therapeutic
SUMMARYMany industrially-relevant enzymes are active, but are severely limited by thermodynamic, kinetic, or stability issues. A Tufts University investigator and their research team has developed an isomerization protocol using a novel biocatalyst to overcome thermodynamic issues in the conversion of galactose into tagatose. This protocol has demonstrated...
Published: 6/7/2022
Inventor(s): Nikhil Nair, Joseph Bober
Category(s): Biomaterials
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