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Novel treatment for CTNNB1 syndrome
SUMMARY
Tufts University investigator, Michelle Jacob, and Broad Institute’s Florence Wagner, have shown significant improvements in symptoms of CTNNB1 neurodevelopmental disorder in a heterozygous mouse model using a novel small molecule targeting β-catenin signaling.
BACKGROUND
The CTNNB1 mutation is an extremely rare genetic neurodevelopmental...
Published: 4/29/2024
Inventor(s): Michele Jacob, Jonathan Alexander, Florence Wagner
Keywords(s):
Category(s): Therapeutic, Therapeutic: small molecule
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AdipoAI: An Adiponectin Receptor Agonist for Treatment of Inflammation and Diabetes
BACKGROUND
Adiponectin (APN) is an endogenous protein hormone which binds to Adiponectin Receptors 1 and 2 to exert an anti-inflammatory response and regulate glucose and fatty acid metabolism. Low APN levels in serum are associated with an increased risk of metabolic diseases and inflammatory disorders such as Type 2 Diabetes (T2D), heart disease,...
Published: 4/29/2024
Inventor(s): Jinkun (Jake) Chen, Qisheng Tu, Xingwen Wu
Keywords(s):
Category(s): Therapeutic, Therapeutic: anti-inflammatory, Therapeutic: small molecule
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New Neisseria gonorrhoeae Vaccine Antigens Expressed During Natural Mucosal Infection
SUMMARY
Researchers at Tufts University discovered novel antigens for a gonococcal vaccine through a unique candidate antigen selection strategy. In vivo, these previously unconsidered protein antigens induce a strong cross-reactive antibody response against diverse Gonorrhea strains
PROBLEM
Neisseria gonorrhoeae, a sexually transmitted infection,...
Published: 6/7/2022
Inventor(s): Caroline Genco, Paola Massari
Keywords(s):
Category(s): Therapeutic: vaccine, Therapeutic
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Novel IL-38 Analogues are Potent Inhibitors of Neuroinflammatory Mediators
SUMMARY
A Tufts University investigator and their collaborators at R&D Systems Inc., have developed novel IL-38 analogues to treat neuroinflammatory and neurodegenerative diseases like Autism Spectrum Disorder (ASD). The novel analogues have demonstrated the ability to be potent inhibitors of proinflammatory mediators secreted from human adult...
Published: 3/2/2023
Inventor(s): Theoharis Theoharides
Keywords(s):
Category(s): Therapeutic
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Novel Non-Flushing Niacin Derivatives and Mimetics
SUMMARY
A researcher from the Tufts University School of Medicine has developed novel derivatives of Niacin, which do not produce the uncomfortable side effect of flushing and reddening of the skin, liver toxicity, or blood glucose changes in patients after high dose treatments.
Problem
Hyperlipidemia and hypercholesterolemia are conditions that...
Published: 10/25/2022
Inventor(s): William Bachovchin, Hung-Sen (Jack) Lai
Keywords(s):
Category(s): Therapeutic
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VF-24: A Unique Mixture of Fruits & Vegetables that Prevent Chronic Diseases and Promote Healthy Aging
SUMMARY
A Tufts University investigator and their team has developed a novel plant-based powder formulated with freeze dried fruits and vegetables to reduce obesity and promote healthy aging. VF-24 is a simple and effective solution, demonstrated through preclinical testing to reduce obesity, hearth disease, risk for cancer and encourage health aging....
Published: 6/4/2024
Inventor(s): Simin Nikbin Meydani, Mohsen Meydani
Keywords(s):
Category(s): Therapeutic
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The Combination of Curcumin and Vitamin B6 in the prevention of colorectal tumorigenesis and inflammation related to excess adiposity
SUMMARYTufts University investigator, Joel Mason and his team, has discovered a novel drug with Curcumin and Vitamin B6 that effectively alters pro-oncogenic inflammatory pathways trigged by obesity. This regimen has demonstrated the ability to significantly reduce tumor multiplicity and tumor burden in obese mice. PROBLEM Colorectal cancer (CRC) is...
Published: 9/30/2020
Inventor(s): Joel Mason, Xian Wu
Keywords(s):
Category(s): Therapeutic
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Methodology to Engineer Amino Acid Ammonia Lyase Enzymes
SUMMARY
Tufts University investigator Nikhil Nair and his team have developed a novel directed evolution workflow to rapidly engineer ammonia lyase (AL) class enzymes for large sequences that are ideal for improving kinetic properties. This technique was used to isolate previously unexplored phenylalanine ammonia lyase (PAL) enzymes with ~2.5-fold...
Published: 8/24/2023
Inventor(s): Nikhil Nair, Karishma Mohan, Vikas Trivedi, Zachary Mays, Todd Chappell
Keywords(s):
Category(s): Therapeutic
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Synthesis and Prophylactic Use of Humanized Neutralizing Monoclonal SLT-I and SLT-II Antibodies Against Hemolytic Uremic Syndrome (HUS) in Children.
The invention relates in one aspect to a therapeutic method to treat hemolytic uremic syndrome by administering to an individual a therapeutically effective amount of monoclonal antibody which binds specifically to either Shiga toxin, Shiga like toxin I or Shiga like toxin II. The hemolytic uremic syndrome is typically caused by an Enterohemorrhagic...
Published: 11/25/2022
Inventor(s): Saul Tzipori, Ramaswamy Balakrishnan, Arthur Donohue-Rolfe
Keywords(s):
Category(s): Therapeutic
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Chemical modification of proteins and peptides for therapy
A series of stimulus-responsive protein modifications to enhance intracellular protein drug delivery.Download a .pdf version of this invention hereIntellectual PropertyUS Publication 2016-0129120
Published: 4/16/2021
Inventor(s): Qiaobing Xu, Ming Wang
Keywords(s):
Category(s): Healthcare, Materials, Nanotechnology, Therapeutic
