Search Results - therapeutic%3a+vaccine

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New Neisseria gonorrhoeae Vaccine Antigens Expressed During Natural Mucosal Infection
SUMMARY Researchers at Tufts University discovered novel antigens for a gonococcal vaccine through a unique candidate antigen selection strategy. In vivo, these previously unconsidered protein antigens induce a strong cross-reactive antibody response against diverse Gonorrhea strains PROBLEM Neisseria gonorrhoeae, a sexually transmitted infection,...

Published: 6/7/2022

Inventor(s): Caroline Genco, Paola Massari

Keywords(s):

Category(s): Therapeutic: vaccine, Therapeutic

Highly Stereoselective Glycosylation Reactions
Researchers at Tufts University have developed a new method to generate 1,2-cis-a-glycosides without the need for specialized directing groups. The new synthetic approach uses thioglycoside donors, which are shelf-stable and easily adapted to one-pot oligosaccharide synthesis. This is a critical technological development for the iterative synthesis...

Published: 6/5/2020

Inventor(s): Clay Bennett, An-Hsiang Chu

Keywords(s):

Category(s): Chemistry, Chemistry: organic compounds, Therapeutic: cell signalling, Therapeutic: small molecule, Therapeutic: vaccine

Spore Vaccine for Rotavirus
Heat-stable, injection-free vaccine platformThe invention is a novel vaccine platform utilizing the non-pathogenic bacterium Bacillus subtilis as the antigen-producer. A desired antigen can be engineered to be under the control of a pro-vegetative state or a pro-sporulation promoter. Cells are induced to express the desired antigen on the cell surface...

Published: 7/30/2021

Inventor(s): John Herrmann, Abraham Sonenshein, Saul Tzipori, Boris Belitsky

Keywords(s):

Category(s): Therapeutic: vaccine

Novel Cholera Vaccine Consisting of Outer Membrane Vesicles
Cholera remains a persistent threat in the developing world, where clean drinking water is scarce. Due to lack of access to adequate medical facilities and the epidemic nature of the disease, a cholera vaccine is the most viable option for dealing with the disease in endemic areas. However, current vaccine formulations are ineffective as they are too...

Published: 3/27/2025

Inventor(s): Andrew Camilli, Eric Nelson, Stefan Schild

Keywords(s):

Category(s): Therapeutic: vaccine