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Novel treatment for CTNNB1 syndrome
SUMMARY
Tufts University investigator, Michelle Jacob, and Broad Institute’s Florence Wagner, have shown significant improvements in symptoms of CTNNB1 neurodevelopmental disorder in a heterozygous mouse model using a novel small molecule targeting β-catenin signaling.
BACKGROUND
The CTNNB1 mutation is an extremely rare genetic neurodevelopmental...
Published: 4/29/2024
Inventor(s): Michele Jacob, Jonathan Alexander, Florence Wagner
Keywords(s):
Category(s): Therapeutic, Therapeutic: small molecule
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AdipoAI: An Adiponectin Receptor Agonist for Treatment of Inflammation and Diabetes
BACKGROUND
Adiponectin (APN) is an endogenous protein hormone which binds to Adiponectin Receptors 1 and 2 to exert an anti-inflammatory response and regulate glucose and fatty acid metabolism. Low APN levels in serum are associated with an increased risk of metabolic diseases and inflammatory disorders such as Type 2 Diabetes (T2D), heart disease,...
Published: 4/29/2024
Inventor(s): Jinkun (Jake) Chen, Qisheng Tu, Xingwen Wu
Keywords(s):
Category(s): Therapeutic, Therapeutic: anti-inflammatory, Therapeutic: small molecule
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Inhibitors of Clostridium difficile spore germination and outgrowth
Inhibitors of Clostridium difficile spore germinationTufts case T001523Technology• Spore formation by Clostridium difficile is a significant obstacle to overcoming hospital-acquired C. difficile-associated disease (CDAD). Spores are resistant to heat, radiation, chemicals, and antibiotics, making a contaminated environment difficult to clean....
Published: 3/19/2021
Inventor(s): Abraham Sonenshein, Joseph Sorg
Keywords(s):
Category(s): Diseases: infectious, Screening: target, Therapeutic: antibiotic, Therapeutic: small molecule
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Novel small molecule inhibitors of phosphatidylinositol-3,4,5-trisphosphate (PIP3)
Why is the target important?The PI3 lipid kinase (PI3K) pathway is an important target for anti-cancer drug development because:It’s activated by growth factors, oncogenes (RAS), GPCRs, etc. It regulates an array of critical cellular functions, including survival, proliferation, metabolism and cell motility. PI3K and its downstream effectors are...
Published: 3/19/2021
Inventor(s): Alexei Degterev, Benchun Miao, C.v. Ramana
Keywords(s):
Category(s): Diseases: cancer, Therapeutic: small molecule
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Highly Stereoselective Glycosylation Reactions
Researchers at Tufts University have developed a new method to generate 1,2-cis-a-glycosides without the need for specialized directing groups. The new synthetic approach uses thioglycoside donors, which are shelf-stable and easily adapted to one-pot oligosaccharide synthesis. This is a critical technological development for the iterative synthesis...
Published: 6/5/2020
Inventor(s): Clay Bennett, An-Hsiang Chu
Keywords(s):
Category(s): Chemistry, Chemistry: organic compounds, Therapeutic: cell signalling, Therapeutic: small molecule, Therapeutic: vaccine
